GLP-1 Agonists: Optimizing Therapy Across Clinical Scenarios

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Course Overview
Review clinical guidance on optimizing use of GLP-1 receptor agonists (RAs) for managing type 2 diabetes and weight loss, as well as their role in cardiovascular and kidney diseases. Learn strategies for therapy continuation during payer changes and medication shortages as well as special considerations for compounded products and perioperative management.

Learning Outcomes
Upon the completion of this course, the learner should be able to:

  • Compare the efficacy of GLP-1 receptor agonists for type 2 diabetes and weight loss.
  • Summarize the evidence of certain GLP-1 receptor agonists in cardiovascular and kidney disease.
  • Explain strategies to continue GLP-1 receptor agonist therapy when changes in payer preference or shortages arise, including approaches for switching among products.
  • Discuss the risks and benefits of alternative GLP-1 receptor agonist dosing practices.
  • Describe considerations for safe use of compounded GLP-1 receptor agonists.
  • List clues for identifying counterfeit GLP-1 receptor agonists.
  • Identify approaches for managing GLP-1 receptor agonists around surgery.
  • Apply therapeutic and operational recommendations in case-based scenarios to help improve outcomes.

About the Author/Presenter
Sara Klockars, PharmD, BCPS, is an Associate Editor at TRC Healthcare. She earned her Doctor of Pharmacy degree from Ohio Northern University and completed PGY1 and PGY2 residencies at the Medical University of South Carolina. Before joining TRC in 2019, Sara worked as a Clinical Pharmacy Specialist at Kaiser Permanente Colorado, collaborating with prescribers and pharmacists in an integrated healthcare system. She spent 12 years in primary care and developed a specialty in dermatology, where she practiced for four years. Her professional interests include pharmacist and prescriber education, evidence-based medicine, cost-effective care, and specialty pharmacy areas such as rheumatology and gastroenterology.

Daphne Berryhill, RPh, is a clinical pharmacist, medical writer, and reviewer. She currently works part-time as an oncology infusion pharmacist in Madison, Wisconsin. In addition, she is a contributor to GoodRx Health, Forbes Health, and HealthDay News. Previous pharmacist roles include home infusion and anticoagulation. Daphne graduated from Chicago College of Pharmacy at Midwestern University in 1999 with a bachelor's degree.

Audience/Accreditations and Approvals
TRC Healthcare/ NetCE
In support of improving patient care, this activity has been planned and implemented by TRC Healthcare/ NetCE. TRC Healthcare/NetCE is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

This course is designed for the following healthcare professions (select your profession for details):

Nursing, Physician

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